We discovered Large Aging Neutrophil-Derived Vesicles (LAND-Vs) and investigate how neutrophil-derived vesicles regulate complement activation and inflammation resolution.

We investigate how neutrophils transition from inflammatory effector cells into pro-resolution states that restore tissue homeostasis and terminate excessive inflammation.

We study how aging reshapes neutrophil development, function, and resolution programs, contributing to chronic inflammation and impaired tissue repair.

We investigate the signaling and cytoskeletal mechanisms that control neutrophil migration, adhesion, polarity, and tissue recruitment.

Using bacterial infection and inflammatory disease models, we examine how neutrophils coordinate antimicrobial defense and immune signaling.

We investigate how membrane remodeling, lipid organization, and inflammatory cell death pathways regulate neutrophil function and disease outcomes.